Ameliorative influences of Moringa oleifera leaves extract to protect the fertility from toxicity Cisplatin-induced in male rats
Abstract
Moringa oleifera leaves had contained high amounts of nutritive compounds like total protein, total lipids as well as minerals content (calcium, phosphorus, potassium, iron, and sodium). Moreover, it leaves extract is a good source for natural antioxidant as total phenolic acids, flavonoids compounds, chlorophyll and carotenoids and also antioxidant activity.
The biological experimental observed that the effect of Moringa oleifera leaves extract to protect the fertility from toxicity Cisplatin-induced in male rats. Moringa oleifera leaves extract was improvement oxidative stress and kidney functions. Furthermore, it was protective of the weight of the epididymis, vas deferens, and seminal vesicle as well as activity of serum testosterone (T), dehydroepiandrosterone (DHEA) levels and leptin. Moreover, the Moringa oleifera leaves extract could the improvement the fertility in rats from toxicity Cisplatin-induced when taken rats orally at 400ppm level from Moringa oleifera leaves extract. Histopathological investigation showed a betterment testicular tissue injury in Moringa oleifera therapy groups than the cisplatin group (control positive group).
From the obvious studies, it could be concluded that the Moringa oleifera leaves was influential in improving the toxic impacts of cisplatin on testicular tissue in rats.